Abstract

A new technique, the near-field correlation spectroscopy (NFCS), is introduced which will be useful for monitoring individual binding events between the biomolecular complex precursors and a functionalized nanoparticle core in a physiological fluid. From jumps in the measured correlation times of single particles trapped in nanoapertures in a metal film, one will be able to determine the rate of binding/dissociation events and, most importantly, the nature of the binding entity, for e.g. discriminate the arrival and binding of a pentamer from a hexamer of protein subunits. This report deals only with the initial steps that are required to implement the new technique.

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Dragnea Research is at the forefront of multidisciplinary innovation, exploring the intersection of nanoscale optics, quantum photonics, physical virology, and bio-architected hybrid materials with 3D nanoscale order. Their latest publications highlight groundbreaking advancements in fields such as self-assembly, optics and spectroscopy, and the physical manipulation of virus-like particles (VLPs) for chemical imaging and surface modifications. Drawing from their expertise in using near-field scanning techniques and laser-induced effects, these works showcase how nanoscale phenomena can be harnessed for applications in material science, virology, and beyond. The accompanying visual mosaic underscores the diverse range of their research, from probing molecular dynamics to the development of 3D-ordered structures, all united by a commitment to pushing the boundaries of applied and theoretical science.