Abstract

Assembly pathways of virus-like particles formed from a virus coat protein cage encapsulating a metal nanoparticle were studied by intrinsic fluorescence quenching. Depending on buffer conditions, the in vitro formation of a virus-like particle can take place through cooperative or non-cooperative adsorption of protein subunits on the nanoparticle template. Simple equilibrium models provided estimates for the thermodynamic forces driving the assembly as well as the size of the critical nucleus in the case of cooperative growth.

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Dragnea Research is at the forefront of multidisciplinary innovation, exploring the intersection of nanoscale optics, quantum photonics, physical virology, and bio-architected hybrid materials with 3D nanoscale order. Their latest publications highlight groundbreaking advancements in fields such as self-assembly, optics and spectroscopy, and the physical manipulation of virus-like particles (VLPs) for chemical imaging and surface modifications. Drawing from their expertise in using near-field scanning techniques and laser-induced effects, these works showcase how nanoscale phenomena can be harnessed for applications in material science, virology, and beyond. The accompanying visual mosaic underscores the diverse range of their research, from probing molecular dynamics to the development of 3D-ordered structures, all united by a commitment to pushing the boundaries of applied and theoretical science.